1983•RePub (Erasmus University Rotterdam)Open access
The Staphylococcus Aureus Receptor for Fibronectin
Debra Jan Bibel, Raza Aly, Henry R. Shinefield, Howard Ira Maibach
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Abstract
The Staphylococcus aureus binding site for human fibronectin was determined by unique biologic assays based upon the specific adherence of the bacterium to nasal epithelial cells. Fibronectin treatment of S. aureus caused a reduction in adherence tallies on high granular and fully keratinized cells compared to controls ( p p S. aureus . Only ribitol teichoic acid had this property. Furthermore, fibronectin could neutralize the adherence- blocking ability of teichoic acid, which affects keratinized cells. Thus, teichoic acid seems to be a receptor for fibronectin.