Comparison of Various Anesthesia Induction Methods for the Anesthesia in Elderly Patients in the Abdominal Surgery

Objective: To investigate the anesthesia induction methods in the elderly in surgeries. Methods: 60 cases of elderly patients in the Abdominal Surgery with ASA grade 1 to 3 were selected and randomly divided into three groups; intravenous injection of 4ug/kg of fentanyl and 0.1mg/kg of vecuronium bromide was conducted at first, and then group A was injected with 0.2mg/kg of midazolam, group B with 1.5mg/kg of propofol, and group C with 0.1mg/kg of midazolam and 1.0mg/kg of propofol for anesthesia induction within 1 min, and then the tracheal intubation was conducted. The effective time of anesthesia induction and the circulatory changes, as well as changes of PRA and Ang II values before anesthesia (T0), after anesthesia induction (T1), immediately after intubation (T3), and 5 min after intubation (T3) were observed. Results: The effective time of anesthesia induction was shorter in group C than in group A (P<0.05), and that was similar between group C and group B (P>0.05); compared with T0, the PRA and Ang II values in the three groups showed a decreasing trend at T1, T2 and T3, with the decrease being distinct at T1 (P<0.05); at T2, the PRA and Ang II values were significantly increased in group A (P<0.05), which were remarkably higher than those in group B and group C at the same period (P<0.05). The mean arterial pressure (MAP) and heart rate (HR) at T2 were notably increased in group A (P<0.05), while those were outstandingly reduced at T1 in group B (P<0.05), and group C had mild circulatory changes (P>0.05). The saturation of pulse oximetry (SPO2) was maintained between 97% and 100%. Conclusion: The combined use of midazolam and propofol is the ideal method for anesthesia induction in the elderly.