The effects of polymorphisms identified in genome-wide association studies of never-smoking females on the prognosis of non-small cell lung cancer

A number of genome-wide association studies reported that several variants influenced the risk of lung cancer in never-smoking females. We evaluated the impact of these variants on survival outcome in never-smoking females with non-small cell lung cancer (NSCLC). A total of 190 never-smoking females with NSCLC who underwent curative surgery were enrolled. Eleven variants, which were associated with lung cancer susceptibility in never-smoking females, were genotyped and their associations with survival outcome were analyzed. Among the 11 variants, VTI1A rs7086803 and TP63 rs7631358 affected survival outcomes. The VTI1A rs7086803 G>A was associated with worse overall survival (under a recessive model; hazard ratio = 3.94, 95% confidence interval = 1.56 – 9.95, P = 0.004). The patients with TP63 rs7631358 GA or AA genotypes also showed significantly decreased overall survival compared with those with TP63 rs7631358 GG genotype (hazard ratio = 3.54, 95% confidence interval = 1.06 – 11.8, P = 0.04). These results suggest that VTI1A rs7086803 G>A and TP63 rs7631358 G>A may affect the prognosis of NSCLC in never-smoking females.