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Relationship between GSTT1 genetic polymorphism,smoking and lung cancer susceptibility

Changshan An

Open publisher page 5 citations

Abstract

Objective To investigate the relationship between the genetic polymorphism of GSTT1 and the susceptibility to lung cancer and potential synergetic interactions.Methods PCR-RFLP were used to identify GSTT1 genotype in 100 cases of lung cancer and 135 controls.Results The frequency of GSTT1(-) genotype in lung cancer group and controls was respectively 57% and 41.5%(P0.05).In people with GSTT1(-) genotype,smoking markedly increased the risk of lung cancer(P0.05).In smokers,GSTT1(-) genotype significantly increased the risk of lung cancer(P0.01).In smokers≥ 20 packyears,GSTT1(-) genotype remarkably increased the risk of lung cancer(P0.01).Conclusions GSTT1(-) genotype increases the susceptibility to lung cancer and there may be a synergetic interaction between smoking and GSTT1(-) genotype.

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What this paper is about

Objective To investigate the relationship between the genetic polymorphism of GSTT1 and the susceptibility to lung cancer and potential synergetic interactions.Methods PCR-RFLP were used to identify GSTT1 genotype in 100 cases of lung cancer and 135 controls.Results The frequency of GSTT1(-) genotype in lung cancer group and controls was respectively 57% and 41.5%(P0.05).In people with GSTT1(-) genotype,smoking markedly increased the risk of lung cancer(P0.05).In smokers,GSTT1(-) genotype significantly increased the risk of lung cancer(P0.01).In smokers≥ 20 packyears,GSTT1(-) genotype remarkably increased the risk of lung cancer(P0.01).Conclusions GSTT1(-) genotype increases the susceptibility to lung cancer and there may be a synergetic interaction between smoking and GSTT1(-) genotype.

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Available abstract

Objective To investigate the relationship between the genetic polymorphism of GSTT1 and the susceptibility to lung cancer and potential synergetic interactions.Methods PCR-RFLP were used to identify GSTT1 genotype in 100 cases of lung cancer and 135 controls.Results The frequency of GSTT1(-) genotype in lung cancer group and controls was respectively 57% and 41.5%(P0.05).In people with GSTT1(-) genotype,smoking markedly increased the risk of lung cancer(P0.05).In smokers,GSTT1(-) genotype significantly increased the risk of lung cancer(P0.01).In smokers≥ 20 packyears,GSTT1(-) genotype remarkably increased the risk of lung cancer(P0.01).Conclusions GSTT1(-) genotype increases the susceptibility to lung cancer and there may be a synergetic interaction between smoking and GSTT1(-) genotype.

Key concepts: Lung cancer, Genotype, Genetic predisposition, Polymorphism (computer science), Internal medicine, Medicine, Lung, Biology

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