Effect of Different Solvent Extracts of Potentilla Fulgens L. on Aldose Reductase and Sorbitol Dehydrogenase in &ormoglycemic and Diabetic Mice

Summary The polyol pathway comprising of aldose reductase (AR) and sorbitol dehydrogenase (SDH), converts glucose to fructose is accelerated under elevated glucose concentration. Several biochemical features implicate the polyol pathway as a plausible and important contributor to complications of diabetes. Plant extracts are known to inhibit the enzymes of the polyol pathway. We report here the effect of different fractions of Potentilla fulgens on AR and SDH activity in liver, kidney and eye of normoglycemic and diabetic mice. Administration of these fractions to the normoglycemic and diabetic mice resulted in varying degree of inhibition of the AR and SDH activity in the liver, kidney and eye.