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2010•Unpublished venueRequires access

Effect of Potentilla Fulgens L. Methanolic Extract on Sorbitol Dehydrogenase in Normal and Alloxan-Induced Diabetic Mice

Donkupar Syiem, Suktilang Majaw

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Abstract

Summary Sorbitol dehydrogenase (SDH; NAD+ oxidoreductase, EC 1.1.1.14) is a polyol pathway enzyme that catalyzes the conversion of sorbitol to fructose using NAD+ as a cofactor. The pathway comprising SDH and AR known to be elevated in diabetes and implicated in the pathogenesis of diabetic cataract and microvascular damage of the retina, kidney. We report here the tissue specific inhibition of SDH by methanolic extract of Potentilla fulgens L in normal and diabetic mice. The magnitude of inhibition also varied with the mode of administration.

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Summary Sorbitol dehydrogenase (SDH; NAD+ oxidoreductase, EC 1.1.1.14) is a polyol pathway enzyme that catalyzes the conversion of sorbitol to fructose using NAD+ as a cofactor. The pathway comprising SDH and AR known to be elevated in diabetes and implicated in the pathogenesis of diabetic cataract and microvascular damage of the retina, kidney. We report here the tissue specific inhibition of SDH by methanolic extract of Potentilla fulgens L in normal and diabetic mice. The magnitude of inhibition also varied with the mode of administration.

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Available abstract

Summary Sorbitol dehydrogenase (SDH; NAD+ oxidoreductase, EC 1.1.1.14) is a polyol pathway enzyme that catalyzes the conversion of sorbitol to fructose using NAD+ as a cofactor. The pathway comprising SDH and AR known to be elevated in diabetes and implicated in the pathogenesis of diabetic cataract and microvascular damage of the retina, kidney. We report here the tissue specific inhibition of SDH by methanolic extract of Potentilla fulgens L in normal and diabetic mice. The magnitude of inhibition also varied with the mode of administration.

Key concepts: Polyol pathway, NAD+ kinase, Sorbitol dehydrogenase, Sorbitol, Alloxan, Internal medicine, Endocrinology, Dehydrogenase

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