Aggressive Central Giant Cell Granuloma Mimicking Peripheral Giant Cell Granuloma - A Rare Case Report and Review of Literature

Central giant cell granuloma is a benign lesion that usually occurs within the jaw bones. Giant cell lesions are classified as aggressive and non-aggressive lesions, based on the clinical and radiographic criteria. Non-aggressive lesions in the jaw can be treated successfully by simple curettage with an expected low recurrence rate. Aggressive lesions have recurrence rates as high as 70% after enucleation or curettage. Pharmacologic therapy with intralesional corticosteroids or calcitonin has been used to treat these lesions, based on the assumption that the tumours are inflammatory or the osteoclast is the primary cell of origin respectively. These treatments have produced variable results. Here we report a case of aggressive Central giant cell granuloma which was successfully treated by complete excision and curettage with a one year follow up.