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1999•Japanese Journal of Oral & Maxillofacial SurgeryOpen access

A case of central giant cell granuloma in the mandible.

Yoshikazu Kamino, Hiroyuki Okada, Noriko Saito, Yuzuru Takeda, Hirotsugu Yamamoto, Hideaki NAGURA

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Abstract

A case of central giant cell granuloma (CGCG) arising in the mandible of a 27-year-old woman is reported. The lesion was studied immunohistochemically. Histopathologically, CGCG had two main components, mononuclear stromal cells and multinucleated giant cells. Immunoreactivity for CD68 was moderate in most giant cells and weak to moderate in some mononuclear cells. These findings indicate that the giant cells and mononuclear cells originated from macrophages. The related literature on CGCG in Japan is also reviewed and discussed.

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A case of central giant cell granuloma (CGCG) arising in the mandible of a 27-year-old woman is reported. The lesion was studied immunohistochemically. Histopathologically, CGCG had two main components, mononuclear stromal cells and multinucleated giant cells. Immunoreactivity for CD68 was moderate in most giant cells and weak to moderate in some mononuclear cells. These findings indicate that the giant cells and mononuclear cells originated from macrophages. The related literature on CGCG in Japan is also reviewed and discussed.

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Available abstract

A case of central giant cell granuloma (CGCG) arising in the mandible of a 27-year-old woman is reported. The lesion was studied immunohistochemically. Histopathologically, CGCG had two main components, mononuclear stromal cells and multinucleated giant cells. Immunoreactivity for CD68 was moderate in most giant cells and weak to moderate in some mononuclear cells. These findings indicate that the giant cells and mononuclear cells originated from macrophages. The related literature on CGCG in Japan is also reviewed and discussed.

Key concepts: Central giant-cell granuloma, Giant cell, CD68, Peripheral blood mononuclear cell, Stromal cell, Medicine, Pathology, Lesion

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