PANTOPRAZOLE WITH GLIPIZIDE IN RABBITS.

Summary Both diabetes and gastric ulcer are common health hazards both in terms of morbidity and mortality. In the first part of this investigation, the influence of glipizide (50µg/kg) on the blood glucose levels of healthy albino rabbits was analysed. The results have indicated that glipizide could produce significant hypoglycaemia and peak effect was 39.3±1.09 at 12 th hour. To the same animals pantoprazole at two dose levels 5mg/kg and 10 mg/kg was administered for 1 week and on 8 th day both the drugs (pantoprazole and glipizide) were administered. The blood samples were collected at regular intervals and blood glucose levels were estimated. Pretreatment of pantoprazole (5mg/kg) for 7 days has shown (40.9 % ± 8.5) reduction of (blood glucose level) BGL of glipizide and at high dose (10mg/kg) for 7 days exhibits the reduction of BGL of glipizide significantly from 39.3±1.09 to 55.1±3.03. In conclusion, the percentage reduction of blood glucose at 24 hours was observed at higher level of 46.9±2.3 indicates the increase in duration of action of glipizide. In conclusion, Pantoprazole has significant increase in the hypoglycemic action of glipizide.