POSSIBLE INTERACTION OF PANTOPRAZOLE ON SULFONYLUREAS IN DIABETIC RATS

Summary The influence of larger dose of pretreatment for seven days on the anti diabetic effect of glibenclamide and glipizide was studied. This study was conducted on alloxan induced diabetic rats of either sex, randomly distributed into 4 different groups. The first two groups were treated with acacia suspension 2%w/v and pantoprazole 30 mg/kg, p.o in 2% w/v gum acacia suspension for seven days and the other two groups (3 and 4) were treated with glibenclamide and glipizide respectively. The animals of the same groups were pretreated with pantoprazole (30 mg/kg) for 7 days. On eighth day, glibenclamide (200 µg/kg, p.o) and glipizide (200 µg/kg, p.o) were administered to respective groups one hour after treatment. Blood samples were collected from retro-orbital sinus at time intervals of 00, 1, 2, 4, 8, 12, 18, and 24 hrs and plasma glucose levels were estimated by GOD/POD method. The onset of glucose reduction, peak effect and duration of action were assessed. The study indicated that higher dose (around 8 times of therapeutic dose) of pantoprazole pretreatment has enhanced the anti diabetic effect of glibenclamide and glipizide significantly. Hence it is suggested that there is no possibility of occurrence of drug interaction during the concomitant usage of therapeutic doses of pantoprazole and sulfonylureas. Therefore the therapeutic drug monitoring and readjustment of the dose and frequency of administration of sulfonylureas are not essential at therapeutic dose levels.