EP25.08: Uterine anomaly and pregnancy failure

The impact of a uterine duplication anomaly on pregnancy outcome remains unclear. There is still lack enough studies evaluating live birthrates and miscarriages in women who had surgery compared with those who did not. The American Fertility Society classification of Müllerian anomalies is the most common standardised classification of uterine anomalies: acuate uterus, bicornuate uterus, unicornuate uterus, septate uterus, subseptate uterus. Objective of the study was to assess the impact of congenital malformations of the uterine on the possibility of becoming pregnant and then give birth at term. This study included 88 nonpregnant women diagnosed with uterine defect. Women were screened for congenital uterine anomalies using a combined two and three -dimensional ultrasound and hysterosalpingography approach. Observation of women was conducted for a period of up to 24 months. In the group of women who became pregnant observation was conducted until birth. In the group of women studied were diagnosed: 21 - acuate uterus, 18 -bicornuate uterus, 5 - unicornuate uterus, 17 - septate uterus, 27 - subseptate uterus. 56 of the 88 analysed women after two years of observation became pregnant. (63,6%); 20 (95,2%) - acutate uterus, 11 (61,1%) - bicornuate uterus, 1 (20%) - unicornuate uterus, 5 (29,4%) - septate uterus, 19 (70,4%) - subseptate uterus. The loss of pregnancy before 22 weeks of pregnancy were reported in 23 (41,1%) observed women: 0 (0%) - acuate uterus, 4 (22,2%) - bicornuate uterus, 2 (40%) - unicornuate uterus, 7 (41,2%) - septate uterus, 10 (37%) - subseptate uterus. In the group of women who gave birth were found 6 (18,2%) delivered before 37 completed weeks of pregnancy. Women with an bicornuate, unicornuate septate or subseptate uterus showed high percentage rates of pregnancy losses (18,2%). Pregnant women with the congenital uterine anomalies have more than twice the risk for preterm labor (18,2%), compared to the population risk (7%).