2010The Chinese Journal of Burns Wounds & Surface UlcersRequires access

Expression and Correlation Study of PTEN and VEGF in Pathological Scar

Bin Liu, Weifeng Liu, Jiang Renwu, Tang Jiang

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Abstract

目的:研究抑癌基因PTEN(第10号染色体丢失的张力蛋白同源的磷酸酶基因)和血管内皮生长因子(VEGF)在病理性瘢痕中的表达及其相关性.方法:应用免疫组化SP法检测正常皮肤、扁平瘢痕、增生性瘢痕和瘢痕疙瘩组织中PTEN、VEGF蛋白的表达并进行统计学分析.结果:病理性瘢痕组织中PTEN蛋白表达显著低于正常皮肤、扁平瘢痕(P<0.05);病理性瘢痕组织中VEGF蛋白表达增高,与正常皮肤、扁平瘢痕对照...

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目的:研究抑癌基因PTEN(第10号染色体丢失的张力蛋白同源的磷酸酶基因)和血管内皮生长因子(VEGF)在病理性瘢痕中的表达及其相关性.方法:应用免疫组化SP法检测正常皮肤、扁平瘢痕、增生性瘢痕和瘢痕疙瘩组织中PTEN、VEGF蛋白的表达并进行统计学分析.结果:病理性瘢痕组织中PTEN蛋白表达显著低于正常皮肤、扁平瘢痕(P<0.05);病理性瘢痕组织中VEGF蛋白表达增高,与正常皮肤、扁平瘢痕对照...

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Available abstract

目的:研究抑癌基因PTEN(第10号染色体丢失的张力蛋白同源的磷酸酶基因)和血管内皮生长因子(VEGF)在病理性瘢痕中的表达及其相关性.方法:应用免疫组化SP法检测正常皮肤、扁平瘢痕、增生性瘢痕和瘢痕疙瘩组织中PTEN、VEGF蛋白的表达并进行统计学分析.结果:病理性瘢痕组织中PTEN蛋白表达显著低于正常皮肤、扁平瘢痕(P<0.05);病理性瘢痕组织中VEGF蛋白表达增高,与正常皮肤、扁平瘢痕对照...

Key concepts: Medicine, PTEN, Pathological, VEGF receptors, Surgery, Pathology, Internal medicine, Apoptosis

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