2006•Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal ChemistryRequires access

Identification of pharmacophores for anti-inflammatory and analgesic activity on aryl-(imidazol-1-yl) acetates

Rajesh Sharma, Parvathi Rao, Shashank Chaturvedi

Abstract

Rofecoxib being a selective cyclooygenase-2 inhibitor has been banned as a non-steroidal anti-inflammatory drug. This has opened new opportunities in the field of research and development of non steroidal anti-inflammatory drugs. In this search, pharmacophores for anti-inflammatory and analgesic activity based on aryl-(imidazol-l-yl) acetates have been identified.

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Available abstract

Key concepts: Pharmacophore, Anti-inflammatory, Analgesic, Aryl, Pharmacology, Drug, Chemistry, Analgesic agents