Synthesis, characterization, analgesic and anti-inflammatory activity of new pyrazole derivatives

The synthesis of nine new pyrazole derivatives was achieved from β-hydroxy enones and hydrazines by using a trace of piperidine in methanol at room temperature.The use of piperidine provides more yield and purity of products in lesser time when compared to the other reagents.All synthetic compounds were characterized by their physical properties, NMR and LC mass spectral data.The pyrazole derivatives were screened for their analgesic and anti-inflammatory activities in vivo.The derivatives exhibited moderate to significant activities in comparison to control, and most of the pyrazoles were competent with standard drugs (Pentazocine and Indomethacin).