Cumulating researches on the relationship between P38 MAPK signaling pathway and gastric carcinoma

The cascade reaction of mitogen-activated protein kinases (MAPKs) is one of the vital intracellular signal transduction systems, participating in many physiological progressions, such as cell growth, proliferation, differentiation and apoptosis. P38 is a member of MAPKs, mediating many cell reactions induced by stress, inflammatory cytokines or bacterial products and playing a key role in the regulation of cell cycle. For different cell lines of gastric carcinoma, P38 has different functions. The same phenomenon can be seen when the cells are presented under different stimulus. P38 pathway may be one candidate target of cancer therapy.