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Biochemical indices of the effects of the selective MAO inhibitors clorgyline, pargyline and deprenyl in man

D.L. Murphy, D. Pickar, D. C. Jimerson, Cohen Rm, Nancy A. Garrick, Farouk Karoum, Robert Wyatt

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Abstract

Drugs which inhibit monoamine oxidase (MAO) affect the metabolism of many biogenic amines and their metabolites. All of the MAO-inhibiting antidepressants available in the USA as prescription drugs are non-selective, and retard the oxidative deamination of the entire list of substrates for the enzyme presented in table 1. These non-selective inhibitors include phenelzine, tranylcypromine and isocarboxazid, as well as such previously widely used drugs as nialamide and iproniazid. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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What this paper is about

Drugs which inhibit monoamine oxidase (MAO) affect the metabolism of many biogenic amines and their metabolites. All of the MAO-inhibiting antidepressants available in the USA as prescription drugs are non-selective, and retard the oxidative deamination of the entire list of substrates for the enzyme presented in table 1. These non-selective inhibitors include phenelzine, tranylcypromine and isocarboxazid, as well as such previously widely used drugs as nialamide and iproniazid. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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OpenAlex reports 15 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Drugs which inhibit monoamine oxidase (MAO) affect the metabolism of many biogenic amines and their metabolites. All of the MAO-inhibiting antidepressants available in the USA as prescription drugs are non-selective, and retard the oxidative deamination of the entire list of substrates for the enzyme presented in table 1. These non-selective inhibitors include phenelzine, tranylcypromine and isocarboxazid, as well as such previously widely used drugs as nialamide and iproniazid. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Key concepts: Clorgyline, Pargyline, Monoamine oxidase, Iproniazid, Phenelzine, Nialamide, Oxidative deamination, Tranylcypromine

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