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The role of p38 mitogen-activated protein kinase (MAPK) in human T cell effector functions

Francis Dodeller, Hendrik Schulze‐Koops

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Abstract

Copyright information:Taken from "The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells"Arthritis Research & Therapy 2006;8(2):205-205.Published online 17 Feb 2006PMCID:PMC1526596. The activation of p38 MAPK in T cells downstream of the T cell receptor and CD28 is necessary for the expression of IL-10 and of the T helper type 2 (Th2) cytokines IL-4, IL-5, and IL-10, but not for that of the Th1 cytokine IFN-γ. In Th1 cells, however, p38 MAPK is involved in the expression of IL-12-induced IFN-γ production.

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What this paper is about

Copyright information:Taken from "The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells"Arthritis Research & Therapy 2006;8(2):205-205.Published online 17 Feb 2006PMCID:PMC1526596. The activation of p38 MAPK in T cells downstream of the T cell receptor and CD28 is necessary for the expression of IL-10 and of the T helper type 2 (Th2) cytokines IL-4, IL-5, and IL-10, but not for that of the Th1 cytokine IFN-γ. In Th1 cells, however, p38 MAPK is involved in the expression of IL-12-induced IFN-γ production.

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Available abstract

Copyright information:Taken from "The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells"Arthritis Research & Therapy 2006;8(2):205-205.Published online 17 Feb 2006PMCID:PMC1526596. The activation of p38 MAPK in T cells downstream of the T cell receptor and CD28 is necessary for the expression of IL-10 and of the T helper type 2 (Th2) cytokines IL-4, IL-5, and IL-10, but not for that of the Th1 cytokine IFN-γ. In Th1 cells, however, p38 MAPK is involved in the expression of IL-12-induced IFN-γ production.

Key concepts: Protein kinase A, Mitogen-activated protein kinase, Effector, Cell biology, MAPK/ERK pathway, p38 mitogen-activated protein kinases, Kinase, Biology

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