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[Pathological and immunohistochemical studies on primary nasal mucosal malignant melanoma].

Xu Jie, L Chen, P Wang

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Abstract

The pathological and immunohistochemical features of primary nasal mucosal malignant melanoma (PNMMM) were reported in 40 cases. The results showed that approximate 70% of PNMMM was polypoid. The principal features were the mixed existance of different cellular patterns and morphologies. Immunohistochemically, PNMMM reactivity to S-100 protein and vimentin was 90% and 77.5%, respectively, along with no reactivity to Keratin. We believe that PNMMM may arise from preexistant melocytes in nasal mucosa. Histological pleomorphism and immunohistochemical reactivity to S-100 protein and vimentin were of importance for diagnosis of PNMMM, especially for the amelanotic type.

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What this paper is about

The pathological and immunohistochemical features of primary nasal mucosal malignant melanoma (PNMMM) were reported in 40 cases. The results showed that approximate 70% of PNMMM was polypoid. The principal features were the mixed existance of different cellular patterns and morphologies. Immunohistochemically, PNMMM reactivity to S-100 protein and vimentin was 90% and 77.5%, respectively, along with no reactivity to Keratin. We believe that PNMMM may arise from preexistant melocytes in nasal mucosa. Histological pleomorphism and immunohistochemical reactivity to S-100 protein and vimentin were of importance for diagnosis of PNMMM, especially for the amelanotic type.

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Available abstract

The pathological and immunohistochemical features of primary nasal mucosal malignant melanoma (PNMMM) were reported in 40 cases. The results showed that approximate 70% of PNMMM was polypoid. The principal features were the mixed existance of different cellular patterns and morphologies. Immunohistochemically, PNMMM reactivity to S-100 protein and vimentin was 90% and 77.5%, respectively, along with no reactivity to Keratin. We believe that PNMMM may arise from preexistant melocytes in nasal mucosa. Histological pleomorphism and immunohistochemical reactivity to S-100 protein and vimentin were of importance for diagnosis of PNMMM, especially for the amelanotic type.

Key concepts: Immunohistochemistry, Vimentin, Medicine, Pathology, Pathological, Keratin, Pleomorphism (cytology), Mucosal melanoma

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[Pathological and immunohistochemical studies on primary nasal mucosal malignant melanoma]. — Research Paper | ScholarLens