2004•Indian Journal of Pharmaceutical SciencesRequires access
Surface Activity Of Cox-2 Inhibitors
Neelam Seedher, Sonu Bhatia
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Abstract
Surface tension of four cox-2 inhibitors, celecoxib, rofecoxib, meloxicam and nimesulide has been determined at 20°. Surface activity has been expressed in terms of surface pressure, surface excess and the area occupied on the liquid surface per drug molecule. Rofecoxib was not found to be surface active. Amongst other drugs, surface activity varied as nimesulide