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[Gastric perfusion in the rat--a method for determining gastric secretion].

Roxie M. Albrecht, W. Nowak, WOLFGANG BLECH

Abstract

The response of the 3 postulated receptors in the parietal cell was investigated by means of a perfusion model in the rat. It was compared the effect of cimetidine and atropine on pentagastrin, histamine and carbachol stimulated gastric acid secretion with a control group. Atropine blocked the carbachol stimulation totally but did not effect pentagastrin and histamine stimulation. Cimetidine inhibited all stimulations. This method is a model for study of drugs influences of the gastric secretion.

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Available abstract

Key concepts: Cimetidine, Carbachol, Pentagastrin, Histamine, Atropine, Stimulation, Parietal cell, Secretion