1980•British journal of surgeryOpen access

The effect of histamine and histamine antagonists on gastric acid secretion and mucosal blood flow in man

S E Knight, Richard L. McIsaac, C D Rennie

Abstract

Histamine has been investigated for its effect on gastric acid secretion and mucosal blood flow in man. Dose-response curves were constructed and analysed in the presence of H1- and H2-antagonists. Mepyramine had no effect on acid secretion or mucosal blood flow. Cimetidine reduced acid secretion but had no effect on blood flow. This suggests that the vasculature is less sensitive to cimetidine than the parietal cell.

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Key concepts: Cimetidine, Histamine, Mepyramine, Medicine, Secretion, Gastric acid, Blood flow, Histamine H2 receptor