Which Is Most Effective In Prevention Of Postoperative Intraperitoneal Adhesions - Methylene Blue, Low Molecular Weight Heparin Or Vitamin E: An Experimental Study In Rats

Background: Postoperative intraperitoneal adhesions and their complications are still serious problems, which are complicating abdominal surgery. Aim: To asses the effects of methylene blue, low molecular weight heparin (LMWH) and vitamin E in prevention of postoperative intraperitoneal adhesions. We also aimed to assess which one is the most effective one. Material and Method: 40 Wistar albino rats were divided into four groups. The first group was the control group; methylene blue was given intraperitoneally to the second group, LMWH to the third group and vitamin E to the fourth group. At the 7th postoperative day, the rats were sacrificed by an overdose of ether, and macroscopic staging for adhesions was performed blindly. Results: Adhesion formation in group 2, 3 and 4 was less than in the control group and a statistically significant difference was determined in comparison of those groups (p 0.05). Conclusion: LMWH and vitamin E with their low prices, easy applications and no toxic and side effects may have an alternative clinical application field in prevention of adhesions.