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[Liver regeneration after resection: molecular and cellular mechanism].

Go Wakabayashi, Motohide Shimazu, Masakazu Ueda, Minoru Tanabe, Shigeyuki Kawachi, Masaki Kitajima

Abstract

It has been well established that the liver can regenerate after resection. Liver regeneration is a fundamental mechanism by which the liver responds to injury. This review article discusses molecular and cellular mechanism of liver regeneration, including growth factors and cytokines in the initiation and regulation of liver regeneration, the importance of the liver extracellular matrix and its dynamic effect on hepatocyte growth, and finally, stem cell biology in liver regeneration.

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Available abstract

Key concepts: Liver regeneration, Regeneration (biology), Medicine, Mechanism (biology), Extracellular matrix, Hepatocyte, Cell biology, Liver injury