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2004•The Internet Journal of Thoracic and Cardiovascular SurgeryRequires access

Pharmacologic Manipulation of Systemic Inflammatory Response after Cardiac Surgery

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Abstract

Cardiac surgery and cardiopulmonary bypass (CPB) activate a systemic inflammatory response characterized clinically by alterations in organ system function. Although significant morbidity is rare (approximately 1%-2% of cases) yet most patients undergoing CPB experience some degree of organ dysfunction as a result of activation of the inflammatory response. Various strategies have been developed aiming to reduce systemic inflammatory response and its deleterious effects on organ function after cardiac surgery. This article presents a review of pharmacologic manipulation of systemic inflammatory response after cardiac surgery.

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What this paper is about

Cardiac surgery and cardiopulmonary bypass (CPB) activate a systemic inflammatory response characterized clinically by alterations in organ system function. Although significant morbidity is rare (approximately 1%-2% of cases) yet most patients undergoing CPB experience some degree of organ dysfunction as a result of activation of the inflammatory response. Various strategies have been developed aiming to reduce systemic inflammatory response and its deleterious effects on organ function after cardiac surgery. This article presents a review of pharmacologic manipulation of systemic inflammatory response after cardiac surgery.

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Available abstract

Cardiac surgery and cardiopulmonary bypass (CPB) activate a systemic inflammatory response characterized clinically by alterations in organ system function. Although significant morbidity is rare (approximately 1%-2% of cases) yet most patients undergoing CPB experience some degree of organ dysfunction as a result of activation of the inflammatory response. Various strategies have been developed aiming to reduce systemic inflammatory response and its deleterious effects on organ function after cardiac surgery. This article presents a review of pharmacologic manipulation of systemic inflammatory response after cardiac surgery.

Key concepts: Medicine, Systemic inflammatory response syndrome, Inflammatory response, Cardiopulmonary bypass, Systemic inflammation, Cardiac surgery, Organ dysfunction, Inflammation

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