1986•YAKUGAKU ZASSHIRequires access
Effects of Tannins and Some Related Compounds on Ethanol-Induced Gastric Lesions in the Rat
Satoru Tani, Yuji Sakurai, Yoshikazu Kondo
Open publisher page 2 citations
Abstract
The protective effects of three kinds of typical tannins: gallotannin; tannic acid and gallic acid, ellagitannin; ellagic acid, condensed tannin; bergenin, on ethanol-induced gastric lesions were tested in rats. As the results, ellagic acid and tannic acid showed protective effects. Some related compounds with catechol or its 0-methylate or 0-methyl pyrogallol moiety were tested. However, these compounds did not show statistically significant effects. Since tannins with pyrogallol moiety were effective for ethanol-induced gastric lesions, a mechanism of the protective effects of ellagic acid and tannic acid was examined. Both compounds lost the effects in indomethacin-treated rats. These results suggested that tannins with pyrogallol moiety showed protective effects for ethanol-induced gastric lesions by stimulating the production of prostaglandins in the gastric mucosa.