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[Cellular factors participating in cell transformation].
Akira Hakura, Hiroshi Inoue, M. Koji Owada, Masuo Yutsudo
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Abstract
To clarify the cellular target(s) of onc gene products of Moloney murine sarcoma virus (Mo-MSV), we isolated eight mutant cells that exhibit temperature-sensitivity for transformation by wild type Mo-MSV from F2408 (Fischer rat cell line). These mutant cells showed normal growth and normal Mo-MSV production at the nonpermissive temperature, suggesting that cellular and viral replication are not affected by these cellular mutations. These mutant cells are divided into 3 classes on the bases of temperature-sensitivity for transformation by other tumor viruses such as Kirsten sarcoma virus, Rous sarcoma virus (SRD strain), Fujinami sarcoma virus and Abelson leukemia virus. These results have suggested that several kinds of cellular factors are concerned in transformation by Mo-MSV.