2001•Journal of VirologyOpen access

Infection of Nondividing Cells by Rous Sarcoma Virus

Théodora Hatziioannou, Stephen P. Goff

Abstract

A direct comparison demonstrates that Rous sarcoma virus is capable of infecting aphidicolin-arrested cells 10-fold more efficiently than murine leukemia virus but less efficiently than human immunodeficiency virus. The efficiency of infection of nondividing cells by the three viruses correlates with the respective ability of each viral DNA to enter the nucleus.

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Key concepts: Biology, Rous sarcoma virus, Virology, Virus, Viral transformation, Murine leukemia virus, Leukemia, Genetics