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[Cytochrome P450*2D6 gene polymorphism in Chinese population].

Enxiang Tao, Zhihong Liu, B Chen, Xinghua Pan

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Abstract

OBJECTIVE: To demonstrate the cytochrome P450*2D6(CYP*2D6) gene polymorphism distribution in Chinese. METHODS: The polymorphisms of CYP*2D6 gene in 100 Chinese people were studied with polymerase chain reaction and Xba I restriction fragment length polymorphic (RFLP) techniques. RESULTS: The frequencies of CYP*2D6 gene A, B, D and E mutations were 1%, 6.5%, 0.5% and 1%, respectively; the genotypes of 29kb/29kb,44kb/29kb and 44kb/44kb Xba I RFLP were 38%, 46% and 13%, respectively. It was found that 12% of B mutations were linked with even though A and B mutations were mainly associated with 29kb/29kb genotype. CONCLUSION: The frequencies of the four kinds of CYP*2D6 gene mutation in Chinese were lower than those of the European, but the frequency of Xba I 44kb allele was a little higher.

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What this paper is about

OBJECTIVE: To demonstrate the cytochrome P450*2D6(CYP*2D6) gene polymorphism distribution in Chinese. METHODS: The polymorphisms of CYP*2D6 gene in 100 Chinese people were studied with polymerase chain reaction and Xba I restriction fragment length polymorphic (RFLP) techniques. RESULTS: The frequencies of CYP*2D6 gene A, B, D and E mutations were 1%, 6.5%, 0.5% and 1%, respectively; the genotypes of 29kb/29kb,44kb/29kb and 44kb/44kb Xba I RFLP were 38%, 46% and 13%, respectively. It was found that 12% of B mutations were linked with even though A and B mutations were mainly associated with 29kb/29kb genotype. CONCLUSION: The frequencies of the four kinds of CYP*2D6 gene mutation in Chinese were lower than those of the European, but the frequency of Xba I 44kb allele was a little higher.

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Available abstract

OBJECTIVE: To demonstrate the cytochrome P450*2D6(CYP*2D6) gene polymorphism distribution in Chinese. METHODS: The polymorphisms of CYP*2D6 gene in 100 Chinese people were studied with polymerase chain reaction and Xba I restriction fragment length polymorphic (RFLP) techniques. RESULTS: The frequencies of CYP*2D6 gene A, B, D and E mutations were 1%, 6.5%, 0.5% and 1%, respectively; the genotypes of 29kb/29kb,44kb/29kb and 44kb/44kb Xba I RFLP were 38%, 46% and 13%, respectively. It was found that 12% of B mutations were linked with even though A and B mutations were mainly associated with 29kb/29kb genotype. CONCLUSION: The frequencies of the four kinds of CYP*2D6 gene mutation in Chinese were lower than those of the European, but the frequency of Xba I 44kb allele was a little higher.

Key concepts: Genetics, Restriction fragment length polymorphism, Genotype, Biology, Gene, Polymorphism (computer science), Chinese population, Allele

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