[Drug monitoring in the treatment of 72 patients with aminophylline].

The drug monitoring of serum concentration of Aminophylline by means of HPLC and FPIA to 72 patients suffering from bronchial asthma and asthmatic bronchitis; the relations among the quantities, serum drug concentrations, effects and side-effects of Aminophylline were reported. The results showed that it is necessary to take Aminophylline individually under the guide of drug monitoring. The monitoring should be combined with clinical observation and comprehensive treatment of the diseases. The major values of effective serum concentration of Aminophylline range from 8 to 20 mg/L, while above the value of 20 mg/L, its side-effects will significantly increase. It is safe and effective for asthmatic adult patients (over 55 Kg weight) if the oral dose of Aminophylline is not more than 200 mg Q8h, or for others with continuous asthmatic attacks to be given with 250 mg of Aminophylline intravenously in drip followed by oral dose of the drug 200 mg Bid.