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Metabolic Interrelationship between Folic Acid, Vitamin B12, and the Citrovorum Factor.

VASANT M. DOCTOR, Billy E. Welch, R. W. Perrett, C. L. Brown, Sabit Gabay, J.R. Couch

Open publisher page 14 citations

Abstract

Supplementing a low vit. B12-PGA chick diet with either increasing levels of vit. B12 (30 γ and 500 γ/kg) or increasing levels of PGA (2, 100, and 400 mg/kg) resulted in an increased capacity by the liver homogenates to convert added PGA to CF. The results further suggest that the 2 vitamins may influence the converting enzyme system through different mechanisms. In vitro addition of formate and vit. B12 to the liver homo-genate gave only a slight stimulation of PGA to CF conversion by the liver homogenate.

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What this paper is about

Supplementing a low vit. B12-PGA chick diet with either increasing levels of vit. B12 (30 γ and 500 γ/kg) or increasing levels of PGA (2, 100, and 400 mg/kg) resulted in an increased capacity by the liver homogenates to convert added PGA to CF. The results further suggest that the 2 vitamins may influence the converting enzyme system through different mechanisms. In vitro addition of formate and vit. B12 to the liver homo-genate gave only a slight stimulation of PGA to CF conversion by the liver homogenate.

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Available abstract

Supplementing a low vit. B12-PGA chick diet with either increasing levels of vit. B12 (30 γ and 500 γ/kg) or increasing levels of PGA (2, 100, and 400 mg/kg) resulted in an increased capacity by the liver homogenates to convert added PGA to CF. The results further suggest that the 2 vitamins may influence the converting enzyme system through different mechanisms. In vitro addition of formate and vit. B12 to the liver homo-genate gave only a slight stimulation of PGA to CF conversion by the liver homogenate.

Key concepts: Vitamin B12, Folic acid, Cyanocobalamin, Chemistry, Stimulation, In vitro, Biochemistry, Enzyme

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