The Effect of Insulin upon the Secretory Response to Feeding in Dogs with Selective Vagotomy of the Parietal Cell Mass

Amdrup, B. M. & Griffith, C. A. 1970. The Effect of Insulin upon the Secretory Response to Feeding in Dogs with Selective Vagotomy of the Parietal Cell Mass. Scand. J. Gastroent. 5, 655-665.The study concerns Heidenhain pouch dogs which had undergone selective vagotomy of the parietal cell mass or selective vagotomy plus suprapyloric antrectomy. Other dogs which had undergone appropriate operations were used as comparative controls. Feeding responses alone, and feeding responses in the presence of insulin hypoglycaemia were compared. In the selective vagotomy dogs insulin stimulation of acid secretion was preceded by inhibition. Insulin’s stimulatory effect was reduced in dogs with additional suprapyloric antrectomy. Results suggest that the gastric vagi may sensitise the antral gastrin producing apparatus. Extragastric vagi may in some way inhibit gastric secretion.