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Substituted thiazolidinediones and thio-imidazolidinones: synthesis, structural study and pharmacological activity.

Julianna Ferreira Cavalcanti de Albuquerque, Aníbal Albuquerque, Cristina Azevedo, F. Thomasson, L. S. Galdino, J. Chantegrel, Maria Tereza Jansen de Almeida Catanho, Ivan da Rocha Pitta, Cuong Luu-Duc

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Abstract

Synthesis and physico-chemical properties of six 3-(4-bromophenacyl)-5-arylidene-thiazolidine-2,4-diones and eight 3-(4-chlorobenzyl)-5-arylidene-4-thio-imidazolidine-2-ones are described. These products were synthesized by an aldolisation-crotonisation reaction from aromatic aldehydes and 3-substituted thiazolidine-2,4-diones or 4-thio-imidazolidine-2-ones. Hypoglycemic and peripheral antinociceptive activities were investigated for these compounds.

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Synthesis and physico-chemical properties of six 3-(4-bromophenacyl)-5-arylidene-thiazolidine-2,4-diones and eight 3-(4-chlorobenzyl)-5-arylidene-4-thio-imidazolidine-2-ones are described. These products were synthesized by an aldolisation-crotonisation reaction from aromatic aldehydes and 3-substituted thiazolidine-2,4-diones or 4-thio-imidazolidine-2-ones. Hypoglycemic and peripheral antinociceptive activities were investigated for these compounds.

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Available abstract

Synthesis and physico-chemical properties of six 3-(4-bromophenacyl)-5-arylidene-thiazolidine-2,4-diones and eight 3-(4-chlorobenzyl)-5-arylidene-4-thio-imidazolidine-2-ones are described. These products were synthesized by an aldolisation-crotonisation reaction from aromatic aldehydes and 3-substituted thiazolidine-2,4-diones or 4-thio-imidazolidine-2-ones. Hypoglycemic and peripheral antinociceptive activities were investigated for these compounds.

Key concepts: Imidazolidine, Thio-, Thiazolidine, Chemistry, Combinatorial chemistry, Stereochemistry, Organic chemistry

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Substituted thiazolidinediones and thio-imidazolidinones: synthesis, structural study and pharmacological activity. — Research Paper | ScholarLens