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WELYSSA: a simple tool using mouse monoclonal antibodies for the detection of lyssavirus nucleocapsid in rabies suspected specimens.

Guixia Xu, P Weber, Quan Hu, H Xue, Laurent Audry, C Li, Jianguo Wu, Hervé Bourhy

Open publisher page 7 citations

Abstract

A Monoclonal antibody (MAb)-based capture enzyme-linked immunosorbent assay (ELISA) named WELYSSA was developed for the diagnosis of rabies suspected specimens using prototype viruses from the different genotypes of lyssavirus and from various geographic origins and phylogenetic lineages. It included a panel of 1,660 specimens received for rabies diagnostic testing, and was found to be highly specific (99.9%) and sensitive (97.0%) when compared to other recommended rabies diagnostic methods.

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What this paper is about

A Monoclonal antibody (MAb)-based capture enzyme-linked immunosorbent assay (ELISA) named WELYSSA was developed for the diagnosis of rabies suspected specimens using prototype viruses from the different genotypes of lyssavirus and from various geographic origins and phylogenetic lineages. It included a panel of 1,660 specimens received for rabies diagnostic testing, and was found to be highly specific (99.9%) and sensitive (97.0%) when compared to other recommended rabies diagnostic methods.

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OpenAlex reports 7 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A Monoclonal antibody (MAb)-based capture enzyme-linked immunosorbent assay (ELISA) named WELYSSA was developed for the diagnosis of rabies suspected specimens using prototype viruses from the different genotypes of lyssavirus and from various geographic origins and phylogenetic lineages. It included a panel of 1,660 specimens received for rabies diagnostic testing, and was found to be highly specific (99.9%) and sensitive (97.0%) when compared to other recommended rabies diagnostic methods.

Key concepts: Lyssavirus, Rabies, Virology, Monoclonal antibody, Rabies virus, Rhabdoviridae, Biology, Mononegavirales

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WELYSSA: a simple tool using mouse monoclonal antibodies for the detection of lyssavirus nucleocapsid in rabies suspected specimens. — Research Paper | ScholarLens