2006•Clinical and Vaccine ImmunologyOpen access

A Novel Double-Antigen Sandwich Enzyme-Linked Immunosorbent Assay for Measurement of Antibodies against Rabies Virus

Limin Yang, Liang-Zhen Zhao, Rongliang Hu, Zhen-Sheng Shi, Wen-Jun Liu

Abstract

A novel double-antigen sandwich enzyme-linked immunosorbent assay (ELISA) was developed to measure rabies antibodies in dogs. In contrast to the 4 days required for detecting rabies antibody with conventional rabies antibody virus neutralization assays, this ELISA can be completed in hours, without using live virus, in routine laboratories.

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Key concepts: Rabies virus, Rabies, Virology, Antibody, Antigen, Virus, Neutralization, Biology