[Cell adhesion molecules on platelet].

Platelets are anucleated blood cells that play a fundamental role in the initiation of hemostasis. In addition to platelet adhesion to the extracellular matrix, aggregation or platelet-platelet interaction is a requisite event in hemostasis. Some glycoproteins on platelet membranes mediate adhesion platelets. The glycoprotein (GP) Ib/IX/V complex is important in platelet adhesion and the GPIIb/IIIa complex mediate platelet to platelet interaction. P-selectin is a member of the selectin family and is transferred from secretory granules to the surface of activated platelets. P-selectin may function to mediate the interaction between activated platelets and leucocytes. We reviewed structure, function, biological roles and clinical application of three platelet-associated adhesion molecules.