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[The effect of domperidone and metoclopramide on antral motility (author's transl)].

Schmidt Gf, Thomas Engel, Hartwig Wilhelm Bauer, Alfred Doenicke

Abstract

The effect of domperidone and metoclopramide on antral motility was studied by measuring the intraluminal pressure in the antrum of 10 normal persons and of 8 patients suffering from duodenal ulcer. Both drugs stimulated the rhythmic activity of the antrum. The antiemetic effect and the therapeutic effect of domperidone on complaints by gastrointestinal retention was the result of the influence on gastrointestinal motility, which is similar to that of metoclopramide.

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Available abstract

Key concepts: Domperidone, Metoclopramide, Antrum, Medicine, Motility, Antiemetic, Internal medicine, Anesthesia