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2003•Humana Press eBooksRequires access

Detection of Peroxynitrite-Induced Protein and DNA Modifications

Scott A. Lorch, Richard T. Lightfoot, Hiroshi Ohshima, László Virág, Qiping Chen, Caryn Hertkorn, Marie Weiss, José M. Souza, Harry Ischiropoulos, Vladimir Yermilov, Brigitte Pignatelli, Mituharu Masuda, Csaba Szabó

Open publisher page 18 citations

Abstract

Nitric oxide and superoxide rapidly combine to form a toxic reaction product, peroxynitrite anion (ONOO) ( 1 , 2 ). The oxidant reactivity of peroxynitrite is mediated by an intermediate with the biological activity of the hydroxyl radical. However, this product does not appear to be the hydroxyl radical per se , but peroxynitrous acid (ONOOH) or its activated isomer (ONOOH*) ( 2 ). Peroxynitrite readily reacts with proteins, lipids, and DNA under conditions of inflammation.

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What this paper is about

Nitric oxide and superoxide rapidly combine to form a toxic reaction product, peroxynitrite anion (ONOO) ( 1 , 2 ). The oxidant reactivity of peroxynitrite is mediated by an intermediate with the biological activity of the hydroxyl radical. However, this product does not appear to be the hydroxyl radical per se , but peroxynitrous acid (ONOOH) or its activated isomer (ONOOH*) ( 2 ). Peroxynitrite readily reacts with proteins, lipids, and DNA under conditions of inflammation.

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OpenAlex reports 18 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Nitric oxide and superoxide rapidly combine to form a toxic reaction product, peroxynitrite anion (ONOO) ( 1 , 2 ). The oxidant reactivity of peroxynitrite is mediated by an intermediate with the biological activity of the hydroxyl radical. However, this product does not appear to be the hydroxyl radical per se , but peroxynitrous acid (ONOOH) or its activated isomer (ONOOH*) ( 2 ). Peroxynitrite readily reacts with proteins, lipids, and DNA under conditions of inflammation.

Key concepts: Peroxynitrite, Peroxynitrous acid, Chemistry, Superoxide, Hydroxyl radical, Nitric oxide, DNA, Biochemistry

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