1988•The Canadian Journal of PsychiatryRequires access

Treatment of Tardive Dyskinesia: Preliminary Report on Use of Tetrabenazine

Michael W.B. Watson, David R. Skelton, Fakhreddin Jamali

Abstract

Tetrabenazine has been used for treatment of tardive dyskinesia sporadically over the past twenty years. Dose has usually been decided empirically without assaying blood levels. This report describes 23 cases treated successfully with tetrabenazine. Our method of measuring levels of tetrabenazine and its metabolites in biological samples is described briefly.

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Key concepts: Tetrabenazine, Tardive dyskinesia, Dyskinesia, Medicine, Pharmacology, Psychiatry, Internal medicine, Dopamine