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2013•Clinical NeuropharmacologyRequires access

Tardive Dyskinesia Caused by Tetrabenazine

Peter A. LeWitt

Open publisher page 23 citations

Abstract

OBJECTIVE: Although tetrabenazine is widely used as an effective treatment for chorea and other hyperkinetic movement disorders, it has been associated with rare instances of parkinsonism and acute dystonic reactions. There have been no prior reports of tardive dyskinesia with this drug. METHODS: Case report. RESULTS: Generalized choreiform dyskinesia developed after 10 months of conventional-dosage tetrabenazine treatment, persisting for several weeks after the drug was discontinued. CONCLUSIONS: As might be anticipated from its pharmacological profile, tetrabenazine has the potential to cause tardive dyskinesia. Such an occurrence may be difficult to detect in a clinical population already affected with involuntary movements.

About this research paper

What this paper is about

OBJECTIVE: Although tetrabenazine is widely used as an effective treatment for chorea and other hyperkinetic movement disorders, it has been associated with rare instances of parkinsonism and acute dystonic reactions. There have been no prior reports of tardive dyskinesia with this drug. METHODS: Case report. RESULTS: Generalized choreiform dyskinesia developed after 10 months of conventional-dosage tetrabenazine treatment, persisting for several weeks after the drug was discontinued. CONCLUSIONS: As might be anticipated from its pharmacological profile, tetrabenazine has the potential to cause tardive dyskinesia. Such an occurrence may be difficult to detect in a clinical population already affected with involuntary movements.

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Available abstract

OBJECTIVE: Although tetrabenazine is widely used as an effective treatment for chorea and other hyperkinetic movement disorders, it has been associated with rare instances of parkinsonism and acute dystonic reactions. There have been no prior reports of tardive dyskinesia with this drug. METHODS: Case report. RESULTS: Generalized choreiform dyskinesia developed after 10 months of conventional-dosage tetrabenazine treatment, persisting for several weeks after the drug was discontinued. CONCLUSIONS: As might be anticipated from its pharmacological profile, tetrabenazine has the potential to cause tardive dyskinesia. Such an occurrence may be difficult to detect in a clinical population already affected with involuntary movements.

Key concepts: Tetrabenazine, Tardive dyskinesia, Dyskinesia, Medicine, Pharmacology, Psychiatry, Internal medicine, Schizophrenia (object-oriented programming)

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