Effect of cigarette smoking on serum total cholesterol and high density lipoprotein cholesterol in normal subjects and coronary heart patients.

In the present study, 51 apparently normal volunteers and 34 clinically established coronary heart disease cases were studied. 21 out of 51 normal, and 16 out 34 coronary heart disease cases were cigarette smokers. The cases were divided in two age groups--20 to 40 years, the younger age group and 41 to 60 years, the older age group. Total serum cholesterol and high-density lipoprotein cholesterol of all the cases were determined. The ratio of total cholesterol to high-density lipoprotein cholesterol was significantly higher in all the smoking normal and coronary heart disease smokers. Hence, the higher levels of total cholesterol to high density lipoprotein cholesterol ratio appears to be one of the important parameters to ascertain the development of coronary heart disease in cigarette smokers.