2016•Bioscience Biotechnology and BiochemistryRequires access

Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of HeLa cervical cancer cells

Hai-Sheng Liu, Yu-Huan Gao, Lihong Liu, Wei Liu, Qing‐Wen Shi, Mei Dong, Toshikazu Suzuki, Hiromasa Kiyota

Abstract

The inhibitory effect of 13 taxanes isolated from the Chinese yew (Taxus chinensis var. mairei) on the proliferation of human cervical cancer HeLa cells were examined using an MTT assay. Four compounds having a hydrophobic cinnamate side chain showed antiproliferative activity, which may be due to increased cell permeability.

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Key concepts: HeLa, Taxus, Taxane, MTT assay, Bark (sound), Traditional medicine, Chemistry, Cancer cell