[Effects of isoflavone (ISO) on advanced glycosylation end products (AGEs) in aortae and serum levels of lipid peroxide in ovariectomized rats].

OBJECTIVE: To investigate effects of isoflavone(ISO) on advanced glycosylation end products (AGEs) and lipid peroxide of ovariectomized rats. METHODS: Rats were randomly divided into sham group (Sham), ovariectomized group (OVX) and OVX + ISO group. Rats were ovariectomized, And two weeks later, OVX + ISO group were treated with ISO. Levels of aortic AGEs, lipids and serum lipid peroxide were detected after 13 weeks of treatment. RESULTS: The aortic AGEs, serum triglycerides (TG), oxidated-LDL (OX-LDL) and malondialdehyde (MDA) of the OVX group were higher (P < 0.01, P < 0.05, P < 0.05 and P < 0.01, respectively) and the levels of high density lipoprotein-cholesterol (HDL-C), apolipoproptein A I (apo-AI) and activity of superoxide dismutase (SOD) were lower (P < 0.01, all) than that of the sham group. ISO not only reduced the concentration of aortic AGEs, serum OX-LDL, TC and MDA (P < 0.01, P < 0.05, P < 0.05 and P < 0.05 respectively), but also increased concentration of serum HDL-C, apo-A I and SOD activity (P < 0.01, all). CONCLUSION: ISO could decrease aortic AGEs, serum MDA and OX-LDL, enhance SOD activity and adjust serum lipids, therefore it maybe helpful to cardiovascular system.