1960•OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)Requires access
STUDIES OF IRON METABOLISM IN THE RAT FOLLOWING X-IRRADIATION (EXPERIMENTAL STUDIES WITH RADIOACTIVE IRON). III. DELAYED APPEARANCE OF IRRADIATED BONE MARROW CELLS IN THE PERIPHERAL BLOOD
Munetoshi Maeda, Yasumasa Ando, Shoko Terauchi
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Abstract
The rate of adsorption of Fe/sup 59/ in the femoral bone marrow of a rat after receiving 170 r whole-body irradiation was markedly less than that of a non- irradiated rat, Delayed appearance of labelled erythrocytes was caused by delayed arrival of radioiron into the bone marrow, due to ' slow plasma clearance and enlarged iron pool occurring in the irradiated rat. If only the right hind leg of a rat was irradiated with doses of 100 r, and the Feq concentration curve of its femur was compared with that of the other femur of the same rat, a similar result was obtained. Therefore, the continued high level of serum F/sup 59/ concentration in the irradiated rat could not have occurred unless the ability of radioiron uptske of the irradiated bone mar row had been changed. The recovery of irradiated bone marrow was not complete by 3 days after 100 r partial irradiation to one leg. It was concluded that radiation delays the appearance of labeled bone marrow cells in the peripheral blood. (Abstr. Japan Med., 2, No. 2, Feb. 1962)