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Anti-allotype antibody response in mice: expression of a cross-reactive idiotype and its regulation by auto-anti-idiotypic antibodies in maternally allotype suppressed F1 hybrids.
Cleiton Chiamonti Bona
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Abstract
Anti-IgGb2a allotype antibodies produced by various responder strains of mice expressed a cross-reactive idiotype. This cross-reactive idiotype was evidenced with BAB. 14 and CXBI anti-idiotypic sera raised following immunization with affinity chromatography purified BALB/c anti-CBPC 101 (IgGb2a) antibodies originating from a single BALB/c mouse. F1 hybrids of BALB/c X C.B20 parents, which have been maternally suppressed for IgGb2a allotype as a result of immunization with CBPC 101, produced anti-allotype antibodies lacking cross-reactive idiotype. Furthermore, these mice produced auto-antibodies directed at the IdX of anti-IgGb2a allotypic antibodies.