1987•PubMedOpen access
A cross-reactive idiotype on anti-DNA and lymphocytotoxic antibodies.
P M Lydyard, David Alan Isenberg, B de Sousa, Lorna Mackenzie, Anne Cooke
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Abstract
The possibility that shared idiotypes may be present on antibodies of different specificities was explored using sera from 13 patients with systemic lupus erythematosus. Eleven sera had anti-DNA and seven carried the 16/6 idiotype (ID). Two of the sera with 16/6 ID also had lymphocytotoxic antibodies, the activity of which was blocked by antibody to the 16/6 ID. Our studies reveal that 16/6 ID is present on two antibodies with different binding specificities.