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[Study of the gene expression pattern in the Kkay mouse with type 2 diabetes by genomic-scale gene expression analysis].

Qinghua Guo, Ju-ming Lu, Ling Yin, Changyu Pan

Abstract

OBJECTIVE: To study the genes differentially expressed in the liver of Kkay diabetic and normal mice by genomic-scale gene expression analysis. METHODS: cDNA microarray chips containing 8,192 cDNAs were used to explore the gene expression pattern of Kkay mouse liver. RESULTS: One hundred and fifty-four genes were screened out, including 68 complete cDNAs and expressed sequence tags, and among them 40 genes were up-regulated and 114 genes were down-regulated respectively. CONCLUSION: Most of the gene expression analysis results were consistent with previous study, and the gene expression pattern of Kkay mouse based on cDNA microarray could be used for high-throughout screening out the genes associated with type 2 diabetes.

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Key concepts: Gene, Complementary DNA, Gene expression, Microarray analysis techniques, Microarray, Biology, DNA microarray, Gene expression profiling