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2005•Carcinogenesis,Teratogenesis and MutagenesisRequires access

Inve stigation on the Gene Expression Pattern of Abnormal Limb of Mouse Embryo Following Exposure to MNNG

Guo Miao-li

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Abstract

BACKGROUNDAIM: To analyse the gene expression profiles in abnormal and normal developmental limbs of GD14embryo mice. MATERIAL AND METHODS: A series of expression microarray analysis of abnormal limb were initiated by cDNA microarray which representing a set of8192mice genes. RESULTS: By applying this cDNA microarray we identified287differentially expressed genes,among which73upregulated and214downregulated. CONCLUSION: cDNA microarray for analysis of gene expression patterns is a powerful method to identify teratogenicity-related gene.Further analysis of these differentially expressed genes will be helpful for understanding the molecular mechanism of teratogenicity.

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What this paper is about

BACKGROUNDAIM: To analyse the gene expression profiles in abnormal and normal developmental limbs of GD14embryo mice. MATERIAL AND METHODS: A series of expression microarray analysis of abnormal limb were initiated by cDNA microarray which representing a set of8192mice genes. RESULTS: By applying this cDNA microarray we identified287differentially expressed genes,among which73upregulated and214downregulated. CONCLUSION: cDNA microarray for analysis of gene expression patterns is a powerful method to identify teratogenicity-related gene.Further analysis of these differentially expressed genes will be helpful for understanding the molecular mechanism of teratogenicity.

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Available abstract

BACKGROUNDAIM: To analyse the gene expression profiles in abnormal and normal developmental limbs of GD14embryo mice. MATERIAL AND METHODS: A series of expression microarray analysis of abnormal limb were initiated by cDNA microarray which representing a set of8192mice genes. RESULTS: By applying this cDNA microarray we identified287differentially expressed genes,among which73upregulated and214downregulated. CONCLUSION: cDNA microarray for analysis of gene expression patterns is a powerful method to identify teratogenicity-related gene.Further analysis of these differentially expressed genes will be helpful for understanding the molecular mechanism of teratogenicity.

Key concepts: Complementary DNA, Microarray, Biology, Microarray analysis techniques, Gene, Gene expression, DNA microarray, Genetics

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