2010•PubMedRequires access

[Inhibitory effect of TBN on platelet aggregation in rabbit].

Chang-Lin Xu, Luchen Shan, Yewei Sun, Yuqiang Wang

Abstract

OBJECTIVE: To investigate the inhibitory effect of TBN on rabbit platelet aggregation in vitro and in vivo, and compare with tetramethylpyrazine (TMP). METHODS: To seek out the maximum of platelet aggregation (expressed in percentage) within 5 minutes which was induced by ADP, PAF and AA according to the Born turbidimetric method with a Platelet-Aggregometer. RESULTS: TBN significantly inhibited platelet aggregation induced by ADP, PAF and AA both in vitro and in vivo. TBN was more active than TMP. CONCLUSION: TBN has significant activity inhibiting platelet aggregation induced by ADP, PAF and AA in vitro and in vivo.

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Key concepts: In vivo, Tetramethylpyrazine, Platelet, In vitro, Chemistry, Platelet aggregation, Pharmacology, Inhibitory postsynaptic potential