2003•PubMedRequires access

[Effects of experimental varicocele on the apoptosis of spermatogenic cells in rats].

Changcheng Zhang, An-fang Zhou, Maolin Zhang, Jigang Cao

Abstract

OBJECTIVE: To explore the effects of experimental varicocele on the apoptosis of spermatogenic cells in rats. METHODS: Thirty-two Sprague-Dawley(SD) male rats were randomly divided into four groups: pseudo-operation group, 45 d experimental group, 60 d experimental group and 90 d experimental group. Experimental varicocele was created by partial ligation of left renal vein. The apoptosis number of spermatogenic cells was measured by flow cytometry. RESULTS: No marked apoptosis peak was observed in the control group, but it was observed in all the other groups, and the height of the peak increased with the duration of experiment. CONCLUSIONS: Varicocele can induce apoptosis of large numbers of spermatogenic cells, and the decrease of spermatogenic cells. This may be the mechanism of varicocele causing male sterility.

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Key concepts: Varicocele, Apoptosis, Flow cytometry, Ligation, Left renal vein, Andrology, Spermatogenesis, Biology