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Large-Scale Lipoprotein Lipase Purification from Adipose Tissue

André Bensadoun, Jean W. Hsu, Barry Hughes

Open publisher page 6 citations

Abstract

Lipoprotein lipase (LPL) plays a central role in lipoprotein metabolism. LPL is the major enzyme responsible for the hydrolysis of triglycerides in VLDL and chylomicrons. Following hydrolysis of the triglyceride core of lipoproteins, some of the LPL molecules remain associated with chylomicron remnants and intermediate density lipoproteins (IDL) derived from VLDL. There is now accumulating evidence that these lipase molecules may play a role in the removal of chylomicron remnants and IDL by the liver and other tissues ( 1 – 4 ). This second function of LPL is independent of its catalytic activity. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

About this research paper

What this paper is about

Lipoprotein lipase (LPL) plays a central role in lipoprotein metabolism. LPL is the major enzyme responsible for the hydrolysis of triglycerides in VLDL and chylomicrons. Following hydrolysis of the triglyceride core of lipoproteins, some of the LPL molecules remain associated with chylomicron remnants and intermediate density lipoproteins (IDL) derived from VLDL. There is now accumulating evidence that these lipase molecules may play a role in the removal of chylomicron remnants and IDL by the liver and other tissues ( 1 – 4 ). This second function of LPL is independent of its catalytic activity. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Lipoprotein lipase (LPL) plays a central role in lipoprotein metabolism. LPL is the major enzyme responsible for the hydrolysis of triglycerides in VLDL and chylomicrons. Following hydrolysis of the triglyceride core of lipoproteins, some of the LPL molecules remain associated with chylomicron remnants and intermediate density lipoproteins (IDL) derived from VLDL. There is now accumulating evidence that these lipase molecules may play a role in the removal of chylomicron remnants and IDL by the liver and other tissues ( 1 – 4 ). This second function of LPL is independent of its catalytic activity. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Key concepts: Chylomicron, Lipoprotein lipase, Very low-density lipoprotein, Intermediate-density lipoprotein, Chemistry, Biochemistry, Hepatic lipase, Lipase

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